With wide roads, calm traffic and ample free parking, Berlin is one of the easiest European capitals to navigate by car, though for city centre sightseeing public transport is definitely easier.
Day visitors are advised to Park & Ride; leave your car for free at a dedicated station and continue by S-Bahn train. Arriving on the A10 highway use Buch station; A100 - Innsbrucker Platz; A111 - Jungfernheide; A113 - Bundesplatz; A114 - Pankow; A115 - Heidelberger Platz. 
All cars inside Berlin's S-Bahn railway ring must have an Umwelt-Plakette (environmental badge sticker), which can be ordered online before your trip (for around €30) via the Climate Company, www.umwelt-plakette.de, tel. +49 30 398 87 21 40, or purchased (from €5,50) at Dekra and TÜV garages around Berlin. 

Street smarts
The Prussians certainly missed a trick when they decided it was a really smart idea to number houses up one side of the street and back down the other. Number 1 may well be opposite number 453. Thankfully, most Berlin street name signs indicate which numbers can be found along each block. 
The peculiar German letter ß is pronounced 's', like in street, Straße. 

Some common street-related words: 
Allee - avenue; 
Platz - square; 
Straße - street; 
Tor - gate; 
Ufer - riverbank.